Water → HCID 178527393, compound

HRID 456681Notes

Reaction equation

HRID 456681 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]([C:17]3[C:18](Cl)=[N:19][CH:20]=[CH:21][CH:22]=3)=O)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.O.[NH2:27][NH2:28].O>C(O)C>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]3[C:17]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[NH:28][N:27]=3)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 18436879{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone

Product 1

HCID 178527393HCID 178527393, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone (280 mg, 0.711 mmol) and 359 mg of hydrazine monohydrate (7.11 mmol) were mixed in 4 mL of ethanol. The mixture was stirred at 80° C. overnight (16 hour) and then cooled down to room temperature. Water was added and filtered. Washed with additional water and methanol to collect the product, dried to afford 250 mg (95% yield) of the title compound.

Workup

  1. temperaturecooled down to room temperature
  2. filtrationfiltered
  3. washWashed with additional water and methanol
  4. customto collect the product
  5. customdried

Sources & evidence

ORD record
ord-b4cd261dd8044ae3a7e767a86bf535b7
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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