HCID 86598886, compound → HCID 45093383, compound

HRID 456723Notes

Reaction equation

HRID 456723 reaction equation
[OH:1][C@@H:2]1[C@H:7]([OH:8])[C@@H:6]2[CH2:9][CH2:10][C@H:3]1[C@@H:4]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:5]2[C@@H](C1C=CC=CC=1)C>CO>[OH:1][C@@H:2]1[C@H:7]([OH:8])[C@@H:6]2[CH2:9][CH2:10][C@H:3]1[C@@H:4]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH:5]2

Participants

3

Reactant 1

HCID 86598886HCID 86598886, compound

Product 1

HCID 45093383HCID 45093383, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl (1S,3S,4S,5S,6R)-5,6-dihydroxy-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.2]octane-3-carboxylate obtained in Example 1-1 (4.2 g) was dissolved in methanol (10 mL), and 10% Pd(OH)2—C (800 mg) was added to the solution. The mixture was hydrogenated under H2 (4.0 atm) at room temperature for 2 hrs.

Sources & evidence

ORD record
ord-2ba18a95154f424ca77391bd63efeda0
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

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