Hydrochloric Acid → (2S)-1-{[(1S,3S,4S,5S,6R)-5,6-Dihydroxy-2-azabicyclo [2.2.2]oct-3-yl]carbonyl}-2-pyrrolidinecarbonitrile Hydrochloride

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Reaction Steps

To a solution of tert-butyl (1S,3S,4S,5S,6R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-5,6-dihydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate obtained in Example 1-4 (122 mg) in chloroform (1 mL), was added 4N HCl in dioxane (3 mL) at room temperature. The reaction mixture was stirred for 15 minutes and the organic solvent was removed in vacuo. The residue was triturated with ethyl acetate to give the target compound as a white powder (100 mg).

Provenance & Evidence