Thiourea → 4-Methyloxan-4-amine hydrochloride

HRID 456735Notes

Reaction equation

HRID 456735 reaction equation
[Cl:1]CC([NH:5][C:6]1([CH3:12])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)=O.NC(N)=S>C(O)C.C(O)(=O)C>[ClH:1].[CH3:12][C:6]1([NH2:5])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 184373262-Chloro-N-(4-methyltetrahydro-2H-pyran-4-yl) acetamide

Product 1

HCID 184373724-Methyloxan-4-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 18476134Acetic acid ethanolSolvent

Procedure

To a solution of 2-chloro-N-(4-methyltetrahydro-2H-pyran-4-yl)acetamide obtained in Example 7-2 (630 mg) in ethanol/acetic acid (5/1, 6 mL), was added thiourea (275 mg) at room temperature. The reaction mixture was heated at reflux for 2 hrs.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 hrs

Sources & evidence

ORD record
ord-76f644a0cd824971ac16c92461794708
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

Loading…