HRID456736

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)[C@@H]1C[C@H](F)CN1C(=O)OC(C)(C)C

HCID10977773

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-

C11H18FNO4

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(=O)O

HCID2756017

(4S)-1-tert-Butoxycarbonyl-4-fluoro-L-proline

C10H16FNO4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The crude product of 1-tert-butyl 2-methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate obtained in Example 7-6 (127.5 g) was dissolved in methanol (400 mL) and then 1N NaOH (800 mL) was added at room temperature.