HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (4S)-1-tert-Butoxycarbonyl-4-fluoro-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel- | HCID 10977773 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4S)-1-tert-Butoxycarbonyl-4-fluoro-L-proline | HCID 2756017 | — |
Reaction Steps
The crude product of 1-tert-butyl 2-methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate obtained in Example 7-6 (127.5 g) was dissolved in methanol (400 mL) and then 1N NaOH (800 mL) was added at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-b45e5f7edcba4250ba9ec65e5f3eb41f |
| Source note | uspto-grants-2007_03 |