Hydrochloric Acid → 2-Pyrrolidinecarboxamide, 4-fluoro-, hydrochloride (1:1), (2S,4S)-

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	2-Methyl-2-propanyl (2S,4S)-2-carbamoyl-4-fluoro-1-pyrrolidinecarboxylate	HCID 49760522	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	2-Pyrrolidinecarboxamide, 4-fluoro-, hydrochloride (1:1), (2S,4S)-	HCID 45158917	—

Reaction Steps

tert-Butyl (2S,4S)-2-aminocarbonyl-4-fluoro-1-pyrrolidinecarboxylate obtained in Example 7-8 (46 g) was dissolved in 4N HCl in dioxane (200 mL) and the resulting mixture was stirred for 10 minutes at room temperature. After removal of the solvent, the resulting residue was triturated with ethyl acetate to give the target compound as a white powder (34 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07186731B2
Source dataset	uspto-grants-2007_03
ORD ID	ord-b6c3fc0568024508a411e294f2420d7f
Source note	uspto-grants-2007_03