Thiourea → 2,4,6-Trimethyloxan-4-amine

HRID 456739Notes

Reaction equation

HRID 456739 reaction equation
ClCC([NH:5][C:6]1([CH3:14])[CH2:11][CH:10]([CH3:12])[O:9][CH:8]([CH3:13])[CH2:7]1)=O.NC(N)=S>C(O)C.C(O)(=O)C>[CH3:13][CH:8]1[CH2:7][C:6]([NH2:5])([CH3:14])[CH2:11][CH:10]([CH3:12])[O:9]1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 184373252-Chloro-N-(tetrahydro-2,4,6-trimethyl-2H-pyran-4-yl)acetamide

Product 1

HCID 184373242,4,6-Trimethyloxan-4-amine

Reagents, catalysts & solvents 1

HCID 18476134Acetic acid ethanolSolvent

Procedure

To a solution of 2-chloro-N-(2,4,6-trimethyltetrahydro-2H-pyran-4-yl) acetamide obtained in Example 9-3 (1.85 g) in ethanol/acetic acid (5/1, 15 mL), was added thiourea (705 mg) at room temperature. The reaction mixture was heated at reflux for 2 hrs.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 hrs

Sources & evidence

ORD record
ord-0406e3b2854449c3adf315cb5c868ee7
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

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