反应详情

温度

20 °C

To a solution of tert-butyl [4-methyl-1-(2-pyrazinyl)-4-piperidinyl]carbamate obtained in Example 10-6 (508 mg) in dichloromethane (1 mL), was added trifluoroacetic acid (5 mL), and the mixture was stirred for 30 minutes at 20° C. The resulting mixture was evaporated in vacuo. The residue was neutralized with sodium hydrogencarbonate and extracted with chloroform three times. The organic layer was washed with brine, dried over MgSO4, and concentrated to give the title compound as a pale yellow solid (281 mg).

1. customThe resulting mixture was evaporated in vacuo
2. extractionextracted with chloroform three times
3. washThe organic layer was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated