Trifluoroacetic acid → HCID 17860880, compound

HRID 456746Notes

Reaction equation

HRID 456746 reaction equation
[CH3:1][C:2]1([NH:14]C(=O)OC(C)(C)C)[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1([NH2:14])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178608364-Tert-butoxycarbonylamino-4-methyl-1-(2-pyrazinyl)piperidine

Product 1

HCID 17860880HCID 17860880, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of tert-butyl [4-methyl-1-(2-pyrazinyl)-4-piperidinyl]carbamate obtained in Example 10-6 (508 mg) in dichloromethane (1 mL), was added trifluoroacetic acid (5 mL), and the mixture was stirred for 30 minutes at 20° C. The resulting mixture was evaporated in vacuo. The residue was neutralized with sodium hydrogencarbonate and extracted with chloroform three times. The organic layer was washed with brine, dried over MgSO4, and concentrated to give the title compound as a pale yellow solid (281 mg).

Workup

  1. customThe resulting mixture was evaporated in vacuo
  2. extractionextracted with chloroform three times
  3. washThe organic layer was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-224af9d3ef924a779f61898dd733eeb4
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

Loading…