HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → HCID 86598904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 69134660 | HCID 69134660 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86598904 | HCID 86598904 | — |
Reaction Steps
To a solution of [((1R,3S,4S,6R)-2-(tert-butoxycarbonyl)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-2-azabicyclo[2.2.1]hept-6-yl)oxy]acetic acid obtained in Example 51-2 (260 mg) in dimethylformamide (3.0 mL), was added 28% ammonium hydroxide (0.08 mL), 1-hydroxy-7-azabenzotriazole (117 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (165 mg). The mixture was stirred at room temperature for 12 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-344ae1fdb99b4f36af81a05c2fe3ed27 |
| Source note | uspto-grants-2007_03 |