Ammonium Hydroxide → HCID 86598904, compound

HRID 456751Notes

Reaction equation

HRID 456751 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@H:13]([C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C@H:17]2[C:21]#[N:22])=[O:15])[C@H:12]2[CH2:23][C@@H:9]1[C@H:10]([O:24][CH2:25][C:26](O)=[O:27])[CH2:11]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[NH4+].O[N:32]1C2N=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[NH2:32][C:26](=[O:27])[CH2:25][O:24][C@H:10]1[C@H:9]2[CH2:23][C@H:12]([C@@H:13]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[C:21]#[N:22])=[O:15])[N:8]2[C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:11]1

Participants

6

Reactant 4

HCID 14923Ammonium HydroxideHCID 181649HOAtHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69134660HCID 69134660, compound

Product 1

HCID 86598904HCID 86598904, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of [((1R,3S,4S,6R)-2-(tert-butoxycarbonyl)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-2-azabicyclo[2.2.1]hept-6-yl)oxy]acetic acid obtained in Example 51-2 (260 mg) in dimethylformamide (3.0 mL), was added 28% ammonium hydroxide (0.08 mL), 1-hydroxy-7-azabenzotriazole (117 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (165 mg). The mixture was stirred at room temperature for 12 hrs.

Sources & evidence

ORD record
ord-344ae1fdb99b4f36af81a05c2fe3ed27
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

Loading…