HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 69462855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-Butyl (1R,3S,4S,6R)-6-allyloxy-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-2-azabicyclo[2.2.1]heptane-2-carboxylate | HCID 86598905 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 69462855 | HCID 69462855 | — |
Reaction Steps
To a solution of tert-butyl (1R,3S,4S,6R)-6-allyloxy-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 16-1 (277 mg) in dimethylformamide (5.0 mL) and water (0.45 mL), were added palladium(2) chloride (105 mg) and copper(1) chloride (292 mg). The mixture was stirred vigorously in aerobic condition at room temperature for 3 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07186731B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-c0e5c198c56e4659844cb5e4fc3716b3 |
| Source note | uspto-grants-2007_03 |