HRID456753

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

结构：C=CCO[C@@H]1C[C@@H]2C[C@H]1N(C(=O)OC(C)(C)C)[C@@H]2C(=O)N1CCC[C@H]1C#N

HCID86598905

未命名化合物

PRODUCTS

生成物

结构：CC(=O)CO[C@@H]1C[C@@H]2C[C@H]1N(C(=O)OC(C)(C)C)[C@@H]2C(=O)N1CCC[C@H]1C#N

HCID69462855

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID62652

未命名化合物

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

To a solution of tert-butyl (1R,3S,4S,6R)-6-allyloxy-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 16-1 (277 mg) in dimethylformamide (5.0 mL) and water (0.45 mL), were added palladium(2) chloride (105 mg) and copper(1) chloride (292 mg). The mixture was stirred vigorously in aerobic condition at room temperature for 3 hrs.