HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 456759Generated: October 31, 2026
Hydroxyamine hydrochloride → tert-butyl (1R,3S,4S,6E)-3-[(2S)-2-cyanopyrrolidine-1-carbonyl]-6-hydroxyimino-2-azabicyclo[2.2.1]heptane-2-carboxylate
https://huagongshe.com/reaction/456759
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | tert-Butyl (1R,3S,4S)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate | HCID 86598907 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | tert-butyl (1R,3S,4S,6E)-3-[(2S)-2-cyanopyrrolidine-1-carbonyl]-6-hydroxyimino-2-azabicyclo[2.2.1]heptane-2-carboxylate | HCID 145785765 | — |
Reaction Steps
To a solution of tert-butyl (1R,3S,4S)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 22-1 (296 mg) in ethanol (5 mL) and water (1 mL),were added hydroxylamine hydrochloride (123 mg) and sodium acetate (153 mg). The mixture was stirred at 80° C. for 20 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07186731B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-ac2a8ff429ed4b26a185ddbb10bb8372 |
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| Source note | uspto-grants-2007_03 |
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