HRID456759

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID443297

未命名化合物

HCID517045

Sodium Acetate

C2H3NaO2

结构：CC(C)(C)OC(=O)N1[C@@H]2C[C@@H](CC2=O)[C@H]1C(=O)N1CCC[C@H]1C#N

HCID86598907

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)N1[C@@H]2C[C@@H](C/C2=N\O)[C@H]1C(=O)N1CCC[C@H]1C#N$

HCID145785765

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

To a solution of tert-butyl (1R,3S,4S)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-6-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate obtained in Example 22-1 (296 mg) in ethanol (5 mL) and water (1 mL),were added hydroxylamine hydrochloride (123 mg) and sodium acetate (153 mg). The mixture was stirred at 80° C. for 20 minutes.