1-Phenethylamine, (+)- → HCID 178501625, compound

HRID 456772Notes

Reaction equation

HRID 456772 reaction equation
[CH3:1][O:2][C:3](=[O:8])[CH:4](O)OC.[C:9]1([C@H:15]([NH2:17])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[C:9]1([C@H:15](/[N:17]=[CH:4]\[C:3]([O:2][CH3:1])=[O:8])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 2724791Methyl 2-Hydroxy-2-methoxyacetate

Product 1

HCID 178501625HCID 178501625, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 2-hydroxy-2-methoxyacetic acid methyl ester (151 g) in toluene (300 mL), was added (R)-(+)-1-phenylethylamine (150 g) dropwise. The mixture was then stirred for 1 hr at room temperature. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate, and evaporated to obtain the target compound as a yellow oil. The target compound was used in the next step without further purification.

Workup

  1. extractionThe resulting mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-e02fc679119d4fdf82328c4292738568
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

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