1-Phenethylamine, (+)- → HCID 178501625, compound

Participants

Reaction Steps

To a solution of 2-hydroxy-2-methoxyacetic acid methyl ester (151 g) in toluene (300 mL), was added (R)-(+)-1-phenylethylamine (150 g) dropwise. The mixture was then stirred for 1 hr at room temperature. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate, and evaporated to obtain the target compound as a yellow oil. The target compound was used in the next step without further purification.

Provenance & Evidence