HCID 10859068, compound → HCID 16228805, compound

HRID 456780Notes

Reaction equation

HRID 456780 reaction equation
C1([C@H]([N:9]2[C@H:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C@@H:13]3[CH2:20][CH2:21][C@H:10]2[CH:11]=[CH:12]3)C)C=CC=CC=1>C(O)C>[CH:10]12[CH2:11][CH2:12][CH:13]([CH2:20][CH2:21]1)[C@@H:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[NH:9]2

Participants

3

Reactant 1

HCID 10859068HCID 10859068, compound

Product 1

HCID 16228805HCID 16228805, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl (1S,3S,4R)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.2]oct-5-ene-3-carboxylate (1.1 g) in ethanol (20 mL) was hydrogenated under H2 atmosphere (4 atm) for 2 hrs. After removal of the catalyst by filtration, the solvent was removed in vacuo to give the target compound as a colorless oil (700 mg).

Workup

  1. customfor 2 hrs
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1118eef5711f4d568d1d402945cbd4db
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

Loading…