反应详情

温度

100 °C

(5R)-5-(Azidomethyl)-3-(3-Fluoro-4-iodophenyl)-1,3-oxazolidin-2-one (Intermediate 5, 30.3 g, 72.9 mmol) was stirred in 1,4-dioxane. Bicyclo[2.2.1]hepta-2,5-diene (40.3 g, 437 mmol) was added and the reaction was heated to 100° C. overnight. The brown mixture was filtered and the desired compound was obtained as a light brown solid (14.8 g).

1. filtrationThe brown mixture was filtered