Potassium Carbonate → HCID 135843048, compound

HRID 456808Notes

Reaction equation

HRID 456808 reaction equation
C([O-])([O-])=O.[K+].[K+].[CH3:7][O:8][C:9]1[CH:42]=[CH:41][C:12]2[C:13]([C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:22][CH:23]=4)[N:18](S(C4C=CC(C)=CC=4)(=O)=O)[C:17]=3[CH3:40])=[N:14][O:15][C:11]=2[CH:10]=1>CO>[CH3:7][O:8][C:9]1[CH:42]=[CH:41][C:12]2[C:13]([C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:25][C:26]([F:28])([F:27])[F:29])=[CH:22][CH:23]=4)[NH:18][C:17]=3[CH3:40])=[N:14][O:15][C:11]=2[CH:10]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18438968HCID 18438968, compound

Product 1

HCID 135843048HCID 135843048, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

K2CO3 (3 eq) and 10 (2.5 g, 4.8 mmol) were heated to reflux in aqueous methanol for 2 hours at which time starting material had been consumed. The reaction mixture was concentrated, diluted with EtOAc and washed with brine. The organic layer was dried over Na2SO4 and concentrated. The residue was purified via flash chromatography eluding with 20% EtOAc/hexanes to provide the product as a pale green solid.

Workup

  1. customhad been consumed
  2. concentrationThe reaction mixture was concentrated
  3. additiondiluted with EtOAc
  4. washwashed with brine
  5. dry with materialThe organic layer was dried over Na2SO4
  6. concentrationconcentrated
  7. customThe residue was purified via flash chromatography

Sources & evidence

ORD record
ord-ca793890107247d8b1998bfe0f7602d6
Source dataset
uspto-grants-2007_03
Patent number
US07186746B2

Reaction notes

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