反应详情

In a similar manner as described in step 4 of Example 1, the title compound was prepared from 1-(6-methoxy-2-naphthyl)-4-phenylbutane-1,4-dione (3.00 g, 9.42 mmol), prepared in step 3 of Example 1, and methyl amine (8 M solution in EtOH, 100 mL, 800 mmol). Isolation of the solids by vacuum filtration gave 2-(6-methoxy-2-naphthyl)-1-methyl-5-phenyl-1H-pyrrole as a white solid (2.5 g, 85%), mp 197–198° C. Elemental Analysis for C22H19NO Calc'd: C, 84.31; H, 6.11; N, 4.47. Found: C, 84.47; H, 6.08; N, 4.41.

1. filtrationIsolation of the solids by vacuum filtration