反应详情

In a similar manner as described in step 2 of Example 6, the title compound was prepared from methyl 2-{[6-(1-methyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoate (0.200 g, 0.433 mmol), prepared in the previous step, and 1N NaOH (0.65 mL, 0.65 mmol) in 1.5:1.5:1 THF:MeOH:water (40 mL) with the exception that this reaction was complete after 18 hours (overnight) at ambient temperature. The title compound was isolated as a pale-yellow solid (0.194 g, 100%) and used without further purification, mp 171–173° C. Elemental Analysis for C30H25NO3.0.05 H2O Calc'd: C, 80.35; H, 5.64; N, 3.12. Found: C, 80.38; H, 5.67; N, 3.00.

1. custom(overnight)
2. customat ambient temperature