反应详情

A solution of 1.7 g of 6-methoxy-2(1H)-quinolone (10 mmoles) in 25 mL POCl3 was refluxed for 2 hours. The reagent was removed under reduced pressure and the resulting gum dissolved in CH2Cl2. The solution was washed with aqueous NaHCO3 to remove remaining acid, dried over MgSO4, and then evaporated to afford 2-chloro-6-methoxy-quinoline as a solid.

1. customThe reagent was removed under reduced pressure
2. dissolutionthe resulting gum dissolved in CH2Cl2
3. washThe solution was washed with aqueous NaHCO3
4. customto remove
5. dry with materialdried over MgSO4
6. customevaporated