Phenylboronic Acid → Imidazo[1,2-a]pyrazin-8-amine, N-methyl-3-phenyl-

HRID 457014Notes

Reaction equation

Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH3:12])[C:5]2=[N:4][CH:3]=1.[C:13]1(B(O)O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:12][NH:11][C:10]1[C:5]2[N:6]([C:2]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:3][N:4]=2)[CH:7]=[CH:8][N:9]=1

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 3088360Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl-

Product 1

HCID 10220145Imidazo[1,2-a]pyrazin-8-amine, N-methyl-3-phenyl-Yield 63%

Procedure

Using Method 1, the title compound was prepared from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine (Example 1) and phenylboronic acid (from Aldrich) in 63% yield.

Sources & evidence

ORD record: ord-d2f281d640c3426093a78be31c4bcf12
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07186832B2

Reaction notes

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