反应详情

温度

80 °C

0.07 g (0.00115 mol) of a 60% suspension of sodium hydride in mineral oil is added to a solution of 0.41 g (0.00114 mol) of ethyl 3-cyclopropylamino-2-(2,5-difluoro-4-pyrrol-1-ylbenzoyl)acrylate in 10 ml of anhydrous dioxane. The mixture is heated at 80° C. for 2 hours under a nitrogen atmosphere and left to cool, 30 ml of water are added and the precipitate is filtered off and washed with water to give 0.3 g of a product melting at 216°-9° C.

1. waitleft
2. temperatureto cool
3. filtrationthe precipitate is filtered off
4. washwashed with water