Potassium Iodide → HCID 66758349, compound

HRID 457143Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([CH3:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Br[CH2:16][CH2:17][CH:18]=[C:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[N:29][C:24]=2[CH2:23][O:22][C:21]2[CH:30]=[CH:31][C:32]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:33][C:20]1=2.[I-].[K+]>C(O)(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([CH3:14])[CH2:9][CH2:10][N:11]([CH2:16][CH2:17][CH:18]=[C:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[N:29][C:24]=3[CH2:23][O:22][C:21]3[CH:30]=[CH:31][C:32]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:33][C:20]2=3)[CH2:12][CH2:13]1

Participants

Conditions

Temperature: 80 °C

Procedure

A solution of 4-(2-Chloro-phenyl)-4-methyl-piperidine (0.29 g, 1.38 mmol) in isopropanol (5 mL) was treated with 2-[5-(3-Bromo-propylidene)-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-yl]-propan-2-ol (0.19 g, 0.50 mmol) and catalytic potassium iodide. The solution was stirred at 80° C. for 12 hr, and evaporated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate→87:10:3 ethyl acetate/methanol/triethylamine) to yield 0.062 g (25%) of the title compound, 1H-NMR (CDCl3) ∂: 1.10 (3H, s), 1.58 (6H, s), 1.78 (2H, m), 1.90 (1H, m), 2.10 (2H, m), 2.40 (8H, m), 5.30 (2H, brs), 6.18 (1H, t), 6.79(1H, m), 6.92 (1H, m), 7.19–7.39 (6H, m), 7.42 (1H, m), 7.55 (1H, m), 8.55 (1H, d).

Workup

customevaporated in vacuo
customThe residue was purified by silica gel chromatography (ethyl acetate→87:10:3 ethyl acetate/methanol/triethylamine)

Sources & evidence

ORD record: ord-65ff7ec83c384b68b978ebe53a5add86
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07186729B2

Reaction notes

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