N-Phenylhydroxylamine → 4-(2-oxazolyl)-phenyl-N-phenylnitrone

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(2-oxazolyl)-benzaldehyde (1 eq., 6.3 gm) and N-phenyl-hydroxyamine (1 eq., 3.9 gm) was refluxed in ethanol (100 ml) for 30 minutes and concentrated to a volume of 50 ml. An equal amount (50 ml) of water was added and the mixture was cooled in a refrigerator at 5° C. overnight. White crystals were obtained, which were isolated by filtration and dried, producing 6.7 gm of 4-(2-oxazolyl)-phenyl-N-phenylnitrone.

Provenance & Evidence