Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

HRID 457634Notes

Reaction equation

HRID 457634 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C)=O)([O-])=O>[Pd]>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[C:5]([CH2:14][C:15](=[O:17])[NH:1]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 83569Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Product 1

HCID 6084876-Trifluoromethyloxindole

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
100 °C

Procedure

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100° C. for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-8297bf6395c54394842ec4283eb5610d
Source dataset
uspto-grants-2007_03
Patent number
US07189721B2

Reaction notes

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