反应详情

温度

100 °C

Iron powder (5 g) was added in one portion to 9.8 g of 2′-methoxy-3-nitrobiphenyl-4-acetic acid in 50 mL of glacial acetic acid was heated to 100° C. for 3 hours. The reaction mixture was concentrated to dryness, sonicated in ethyl acetate and filtered to remove the insolubles. The filtrate was washed twice with 1N hydrochloric acid, water and then brine, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on silica gel in ethyl acetate:hexane (1:2) to give 5.4 g of 6-(2-methoxyphenyl)-2-oxindole as a rose colored solid.

1. concentrationThe reaction mixture was concentrated to dryness
2. customsonicated in ethyl acetate
3. filtrationfiltered
4. customto remove the insolubles
5. washThe filtrate was washed twice with 1N hydrochloric acid, water
6. dry with materialbrine, dried over anhydrous sodium sulfate
7. concentrationconcentrated
8. customThe residue was chromatographed on silica gel in ethyl acetate:hexane (1:2)