Tetrahydrofuran → HCID 11340371, compound

HRID 457710Notes

Reaction equation

HRID 457710 reaction equation
CS(NCC[NH:8][C:9]([C:11]1[C:12]([C:32]2[C:37]([Cl:38])=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:39])=[CH:13][C:14]2[CH:19]=[N:18][C:17]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23](SCCO)[CH:22]=3)=[N:16][C:15]=2[N:31]=1)=[O:10])(=O)=O.C[Si](C)(C)[O-:42].[K+].[CH2:46]1[CH2:50][O:49]CC1>>[Cl:39][C:33]1[CH:34]=[CH:35][CH:36]=[C:37]([Cl:38])[C:32]=1[C:12]1[C:11]([C:9]([NH2:8])=[O:10])=[N:31][C:15]2[N:16]=[C:17]([NH:20][C:21]3[CH:22]=[CH:23][C:24]([O:49][CH2:50][CH2:46][OH:42])=[CH:25][CH:26]=3)[N:18]=[CH:19][C:14]=2[CH:13]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 11296412HCID 11296412, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 11340371HCID 11340371, compound

Conditions

Temperature
100 °C

Procedure

20 mg of the product from example 3 in 1 ml THF were mixed with 13.5 mg potassium trimethylsilanolate under Ar atmosphere. The mixture was heated to 100° C. for 20 min in a microwave reactor.

Sources & evidence

ORD record
ord-cf10c01ec2de4d3d978e5c8fbc5e3617
Source dataset
uspto-grants-2007_03
Patent number
US07189732B2

Reaction notes

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