Trifluoroacetic acid → HCID 18440725, compound

HRID 457745Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:22](=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][C:20]=2[NH:24][C:25]([C:27]2[S:28][C:29]([Cl:32])=[CH:30][CH:31]=2)=[O:26])[C:15]1=[O:33])(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:22](=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][C:20]=2[NH:24][C:25]([C:27]2[S:28][C:29]([Cl:32])=[CH:30][CH:31]=2)=[O:26])[C:15]1=[O:33]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 18440736HCID 18440736, compound

Product 1

HCID 18440725HCID 18440725, compound

Procedure

was obtained analogously by reacting tert-butyl-6-(4-{[(5-chloro-2-thienyl)carbonyl]amino}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexylcarbamate with trifluoroacetic acid.

Workup

customwas obtained analogously

Sources & evidence

ORD record: ord-27e413b4c4434244b985aab7f76678e5
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07189738B2

Reaction notes

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