反应详情

Methanol (1 mL) and aqueous sodium hydroxide solution (2M, 1 mL) were added to ethyl 2-(4-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.25 g, 0.77 mmol) and stirred at ambient temperature for 2 hours. The volume was reduced (˜1 mL) by rotary evaporation and the resulting residue treated with aqueous HCl (6N) with stirring to pH 6, resulting in formation of a white precipitate, which was isolated by filtration. The solid was washed with water (6×1 mL), air dried for 1 hour and dried under vacuum over P2O5 overnight to give a white powder (0.072 g, 32%).

1. customby rotary evaporation
2. additionthe resulting residue treated with aqueous HCl (6N)
3. stirringwith stirring to pH 6
4. customresulting in formation of a white precipitate
5. customwhich was isolated by filtration
6. washThe solid was washed with water (6×1 mL), air
7. customdried for 1 hour
8. dry with materialdried under vacuum over P2O5 overnight