Sodium Hydroxide → Propanoic acid, 2-[[4-(4-cyanophenyl)-3-pyridinyl]thio]-2-methyl-

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Reaction Steps

Methanol (1 mL) and aqueous sodium hydroxide solution (2M, 1 mL) were added to ethyl 2-(4-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.25 g, 0.77 mmol) and stirred at ambient temperature for 2 hours. The volume was reduced (˜1 mL) by rotary evaporation and the resulting residue treated with aqueous HCl (6N) with stirring to pH 6, resulting in formation of a white precipitate, which was isolated by filtration. The solid was washed with water (6×1 mL), air dried for 1 hour and dried under vacuum over P2O5 overnight to give a white powder (0.072 g, 32%).

Provenance & Evidence