Hydrochloric Acid → HCID 69420461, compound

HRID 457773Notes

Reaction equation

HRID 457773 reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH:6]1[C:18]1[NH:19][C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([C:27]([NH2:29])=[O:28])=[CH:22][CH:21]=2)(=[O:4])[CH:2]=[CH2:3].C(OC([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)=O)(C)(C)C.Cl>>[N:37]1([CH2:3][CH2:2][C:1]([N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:7][CH:6]2[C:18]2[NH:19][C:20]3[C:25]([CH:26]=2)=[CH:24][C:23]([C:27]([NH2:29])=[O:28])=[CH:22][CH:21]=3)=[O:4])[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 69421423HCID 69421423, compound

Product 1

HCID 69420461HCID 69420461, compound

Procedure

The 1-acryloyl-(4-benzyl)-piperidinyl-indole-5-carboxamide above was reacted with tert-butyl-1-piperazine carboxylate as described before. The product was deprotected using methanolic HCl. M+ 458.

Sources & evidence

ORD record
ord-2aa672388dcc4571a61d0f74882623bf
Source dataset
uspto-grants-2007_03
Patent number
US07189739B2

Reaction notes

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