3-(4-Piperidinyl)-1H-indole → HCID 69411468, compound

HRID 457808Notes

Reaction equation

HRID 457808 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.[CH2:16]([O:18][C:19](=[O:29])[C:20]1[CH:25]=[C:24]([CH2:26]Br)[CH:23]=[CH:22][C:21]=1[F:28])[CH3:17]>>[CH2:16]([O:18][C:19](=[O:29])[C:20]1[CH:25]=[C:24]([CH2:26][N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[NH:9][CH:8]=3)[CH2:3][CH2:2]2)[CH:23]=[CH:22][C:21]=1[F:28])[CH3:17]

Participants

3

Reactant 2

HCID 7022353-(4-Piperidinyl)-1H-indoleHCID 59765446HCID 59765446, compound

Product 1

HCID 69411468HCID 69411468, compoundYield 79%

Procedure

This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3-piperidin-4-yl-1H-indole and 0.33 g (1.3 mmol 5-bromomethyl-2-fluoro-benzoic acid ethyl ester. After ionic exchange purfication, 0.30 g (79% of yield) of 2-fluoro-5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-9da858dcae3a4ba7a43825042ae3fd49
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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