Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate → HCID 69412237, compound

HRID 457818Notes

Reaction equation

HRID 457818 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].CS(O[CH2:26][CH2:27][CH:28]1[CH2:33][O:32][CH2:31][CH2:30][O:29]1)(=O)=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:26][CH2:27][CH:28]3[CH2:33][O:32][CH2:31][CH2:30][O:29]3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylateHCID 86592851HCID 86592851, compound

Product 1

HCID 69412237HCID 69412237, compoundYield 101.3%

Conditions

Temperature
40 °C

Procedure

This compound was prepared following the procedure described in example 13 (part B) starting with 0.47 g (1.2 mmol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.62 g (2.9 mmol) of 2-[1,4]dioxan-2-yl-ethyl methansulfonate. The reaction mixture was stirred at 40° C. for 24 hours. After standard work-up and purification, 0.47 g (51% of yield) of 4-[1-(2-[1,4]dioxan-2-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-5c79b21de3cf4d1bb2bb6e8f9d8c89e3
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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