Methyl 4-Bromo-3-(bromomethyl)benzoate → HCID 10185564, compound

HRID 457823Notes

Reaction equation

HRID 457823 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[CH:8]=2)[CH2:3][CH2:2]1.C[O:24][C:25](=[O:35])[C:26]1[CH:31]=[CH:30][C:29]([Br:32])=[C:28]([CH2:33]Br)[CH:27]=1>>[Br:32][C:29]1[CH:30]=[CH:31][C:26]([C:25]([OH:35])=[O:24])=[CH:27][C:28]=1[CH2:33][N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][C:17]3[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=3)[CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11460987Methyl 4-Bromo-3-(bromomethyl)benzoateHCID 17964331HCID 17964331, compound

Product 1

HCID 10185564HCID 10185564, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 1.5 g (50 mmol) of 3-piperidin-4-yl-1-pyridin-4-ylmethyl-1H-indole and 1.7 g (55 mmol) of 4-bromo-3-bromomethyl-benzoic acid methyl ester. After standard work-up and recrystallisation with ethyl ether, 1.7 g (68% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and recrystallisation

Sources & evidence

ORD record
ord-04e5b194cdf44f03bd2fe2f591eeff6c
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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