HCID 11278467, compound → HCID 10162727, compound

HRID 457834Notes

Reaction equation

HRID 457834 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:7][N:8]2[CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1.C([O:25][C:26](=[O:37])[C:27]1[CH:32]=[C:31]([CH2:33]Br)[CH:30]=[CH:29][C:28]=1[O:35][CH3:36])C>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]3[CH2:18][CH2:19][N:20]([CH2:33][C:31]4[CH:30]=[CH:29][C:28]([O:35][CH3:36])=[C:27]([CH:32]=4)[C:26]([OH:37])=[O:25])[CH2:21][CH2:22]3)=[CH:7][N:8]2[CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11278467HCID 11278467, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 10162727HCID 10162727, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 2.9 g (9.2 mmol) of 6-fluoro-3-piperidin-4-yl-1-thiophen-2-ylmethyl-1H-indole and 2.7 g (11.5 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard work-up, 1.2 g (27% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b0efeb3fa6994ac099df2f41d8c07f6b
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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