3-(Bromomethyl)furan → 4-(1-furan-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester

HRID 457839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457839
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[CH2:22][C:23]1[CH:27]=[CH:26][O:25][CH:24]=1>C(OCC)C>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:22][C:23]3[CH:27]=[CH:26][O:25][CH:24]=3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 110949343-(Bromomethyl)furanHCID 11380267Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

Produkt 1

HCID 694145104-(1-furan-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl esterAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.7 mmol) 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 16 mL (16 mmol) of a freshly prepared 1M solution in ethyl ether of 3-bromomethyl-furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 5.3 g (99% of yield) of 4-(1-furan-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were obtained.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-6731e673eccd420898efd456f3a9c149
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

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