Methyl 2-(bromomethyl)-4-methoxybenzoate → HCID 17964360, compound

HRID 457855Notes

Reaction equation

HRID 457855 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=2)[C:9]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[CH:8]1.C[O:25][C:26](=[O:37])[C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=1[CH2:35]Br>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=2)[C:9]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:35][C:28]3[CH:29]=[C:30]([O:33][CH3:34])[CH:31]=[CH:32][C:27]=3[C:26]([OH:37])=[O:25])[CH2:20][CH2:19]2)=[CH:8]1

Participants

3

Reactant 2

HCID 139928Methyl 2-(bromomethyl)-4-methoxybenzoateHCID 17964350HCID 17964350, compound

Product 1

HCID 17964360HCID 17964360, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.17 mmol) of 1-furan-2-ylmethyl-5-methoxy-3-piperidin-4-yl-1H-indole and 0.057 g (0.22 mmol) of 2-bromomethyl-4-methoxy-benzoic acid methyl ester. After standard work-up and purification by chromatography using a C18 column, 0.029 g (36% of yield) of the expected acid were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification by chromatography

Sources & evidence

ORD record
ord-26d3354d0b5d4bf09777bcbbb4a7faec
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

Loading…