HCID 17964375, compound → HCID 17964319, compound

HRID 457865Notes

Reaction equation

HRID 457865 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH2:16][C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)[CH:8]=2)[CH2:3][CH2:2]1.C([O:24][C:25](=[O:36])[C:26]1[CH:31]=[C:30]([CH2:32]Br)[CH:29]=[CH:28][C:27]=1[O:34][CH3:35])C>>[CH3:35][O:34][C:27]1[CH:28]=[CH:29][C:30]([CH2:32][N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[N:9]([CH2:16][C:17]4[CH:21]=[CH:20][S:19][CH:18]=4)[CH:8]=3)[CH2:3][CH2:2]2)=[CH:31][C:26]=1[C:25]([OH:36])=[O:24]

Participants

3

Reactant 2

HCID 17964375HCID 17964375, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 17964319HCID 17964319, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 0.1 g (0.38 mmol) of 3-piperidin-4-yl-1-thiophen-3-ylmethyl-1H-indole and 0.13 g (0.48 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.002 g (94% of purity) of the expected acid were isolated.

Workup

  1. customThis compound was prepared
  2. customThe crude mixture was purified by HPLC-MS
  3. customwere isolated

Sources & evidence

ORD record
ord-b1a41f63c5f84c8e8c9164c6e88f2475
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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