HCID 17964369, compound → HCID 17964297, compound

HRID 457868Notes

Reaction equation

HRID 457868 reaction equation
[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[C:10]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[CH:9]2)=[CH:4][CH:3]=1.C([O:27][C:28](=[O:39])[C:29]1[CH:34]=[C:33]([CH2:35]Br)[CH:32]=[CH:31][C:30]=1[O:37][CH3:38])C>>[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[C:10]([CH:19]3[CH2:20][CH2:21][N:22]([CH2:35][C:33]4[CH:32]=[CH:31][C:30]([O:37][CH3:38])=[C:29]([CH:34]=4)[C:28]([OH:39])=[O:27])[CH2:23][CH2:24]3)=[CH:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 17964369HCID 17964369, compoundHCID 688939465-Bromomethyl-2-methoxybenzoic acid ethyl ester

Product 1

HCID 17964297HCID 17964297, compound

Procedure

This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.13 mmol) 1-(5-chloro-thiophen-2-ylmethyl)-5-methoxy-3-piperidin-4-yl-1H-indole and 0.05 g (0.18 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.002 g (99% of purity) of the expected acid were isolated.

Workup

  1. customThis compound was prepared
  2. customThe crude mixture was purified by HPLC-MS
  3. customwere isolated

Sources & evidence

ORD record
ord-64e3fa2b975a4b899f65b3b9bd3db022
Source dataset
uspto-grants-2007_03
Patent number
US07189741B2

Reaction notes

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