Palmitic Acid → Hexadecanoic acid [4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-amide

HRID 457887Notes

Reaction equation

HRID 457887 reaction equation
[C:1]([OH:18])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH3:19][C:20]1[N:21]=[C:22]([NH2:31])[S:23][C:24]=1[CH2:25][CH2:26][O:27][N+:28]([O-:30])=[O:29]>>[CH3:19][C:20]1[N:21]=[C:22]([NH:31][C:1](=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[S:23][C:24]=1[CH2:25][CH2:26][O:27][N+:28]([O-:30])=[O:29]

Participants

3

Reactant 2

HCID 985Palmitic AcidHCID 115574994-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine

Product 1

HCID 58820308Hexadecanoic acid [4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-amideYield 62%

Procedure

Pet-158 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using hexadecanoic acid (palmitic acid) and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 62%.

Workup

  1. customPet-158 was prepared
  2. customthe procedure described above for the preparation of Pet-154

Sources & evidence

ORD record
ord-c61251c6aac44607af68f92354e43404
Source dataset
uspto-grants-2007_03
Patent number
US07189750B2

Reaction notes

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