Trifluoromethanesulfonyl chloride → 1,1,1-trifluoro-N-(2-(4-(6-methoxy-napthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-methanesulfonamide

HRID 457895Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]1[N:14]=[C:15]([C:24]([CH3:28])([CH3:27])[CH2:25][NH2:26])[NH:16][C:17]=1[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)[CH:7]=[CH:6]2.[F:29][C:30]([F:36])([F:35])[S:31](Cl)(=[O:33])=[O:32]>>[F:29][C:30]([F:36])([F:35])[S:31]([NH:26][CH2:25][C:24]([C:15]1[NH:16][C:17]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)[N:14]=1)([CH3:28])[CH3:27])(=[O:33])=[O:32]

Participants

Reactant 2

HCID 79000Trifluoromethanesulfonyl chloride

HCID 18440775HCID 18440775, compound

Product 1

HCID 184407581,1,1-trifluoro-N-(2-(4-(6-methoxy-napthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-methanesulfonamideYield 33%

Procedure

The title compound (9 mg, 33%) was prepared starting from the product of Example 2 and 1,1,1-trifluoromethanesulfonyl chloride using the method described in Example 4; MS(ES) m/e 505 [M+H]+.

Sources & evidence

ORD record: ord-ae2689ec02914ff0a820fffe4f922de1
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07189745B1

Reaction notes

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