4-Phenylbenzoyl chloride → Methyl (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylate

HRID 457926노트

반응식

HRID 457926 반응식
[CH3:1][O:2][N:3]=[C:4]1[CH2:8][N:7]([C:9]([O:11]C(C)(C)C)=O)[C@H:6]([C:16]([O:18][CH3:19])=[O:17])[CH2:5]1.[C:20]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:23](C(Cl)=O)=[CH:22][CH:21]=1>>[C:20]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:25]=[CH:24][C:23]([C:9]([N:7]2[CH2:8][C:4](=[N:3][O:2][CH3:1])[CH2:5][C@H:6]2[C:16]([O:18][CH3:19])=[O:17])=[O:11])=[CH:22][CH:21]=1

참가 물질

3

반응물 2

HCID 841514-Phenylbenzoyl chlorideHCID 585854781-tert-butyl 2-methyl (2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate

생성물 1

HCID 91037622Methyl (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylate수율 31%

실험 절차

Following the general methods as outlined in Example 4, starting from 1-tert-butyl 2-methyl(2S,4EZ)-4-(methoxyimino)-1,2-pyrrolidinedicarboxylate and [1,1′-biphenyl]-4-carbonyl chloride, the title compound was isolated, after flash-chromatography, as a mixture of two isomers as an oil in 31% yield (99% purity by HPLC).

출처 및 근거

ORD 기록
ord-e959b42a2b074096912cc50998a4c16f
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189754B2

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