Methanol → HCID 131726296, compound

HRID 457936Notes

Reaction equation

HRID 457936 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=[O:17])=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:21]=[C:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:24][C:25]=1C(O)=O.[CH3:35]O>>[CH3:19][C:20]1[CH:21]=[C:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:24][C:25]=1[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([O:18][CH3:35])=[O:17])=[O:7]

Participants

4

Reactant 3

HCID 887MethanolHCID 140905703-Methyl-[1,1'-biphenyl]-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726296HCID 131726296, compound

Procedure

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3-methyl[1,1′-biphenyl]-4-carboxylic acid, and methanol, the title compound isolated as a mixture of two isomers in 82.3% purity by HPLC.

Sources & evidence

ORD record
ord-523fcb85d5fb42ce860f59c2b20263d6
Source dataset
uspto-grants-2007_03
Patent number
US07189754B2

Reaction notes

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