反应详情

7-Iodoquinazolin-4-one (0.46 g) was treated with phosphorous oxychloride (5 ml) at reflux under nitrogen for 2 hours. The mixture was cooled, evaporated and partitioned between saturated aqueous sodium carbonate and ethyl acetate. The organic phase was dried and concentrated in vacuo to give the title compound (0.43 g); m/z (M+1+) 291.

1. temperatureat reflux under nitrogen for 2 hours
2. temperatureThe mixture was cooled
3. customevaporated
4. custompartitioned between saturated aqueous sodium carbonate and ethyl acetate
5. customThe organic phase was dried
6. concentrationconcentrated in vacuo