8-(2-Hydroxy-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one → Rac-8-(2-oxo-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

HRID 458150Notes

Reaction equation

HRID 458150 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[N:8]1[CH2:24][CH2:23][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][NH:13][C:12]2=[O:22])[CH2:10][CH2:9]1.CC(C)CCN1C2(CCN(C3CCCCC3=O)CC2)C(=O)NC1>>[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][NH:13][C:12]2=[O:22])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 159257968-(2-Hydroxy-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-oneHCID 18441754Rac-1-(3-methyl-butyl)-8-(2-oxo-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one

Product 1

HCID 18441774Rac-8-(2-oxo-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

Procedure

The title compound was prepared from (rac,trans) 8-(2-hydroxy-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one in analogy of the procedure described for the synthesis of rac-1-(3-methyl-butyl)-8-(2-oxo-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one (Example 73d). rac-8-(2-Oxo-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one was obtained as yellow solid, MS (ISP): 328.4 MH+.

Sources & evidence

ORD record
ord-a6a0205061b7435ea0fc0ed0af99ee97
Source dataset
uspto-grants-2007_03
Patent number
US07189850B2

Reaction notes

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