反应详情

A solution of (3-methoxy-4-pent-2-ynyloxy-phenyl)-methanol (27 g, 0.12 mol) in 450 ml of dioxan is added dropwise to 240 ml of concentrated hydrochloric acid. The reaction mixture is stirred for 1.5 hours at room temperature. Subsequently it is poured on water and extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate and evaporated in vacuo to obtain 4-chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene as yellow oil.

1. additionSubsequently it is poured on water
2. extractionextracted with ethyl acetate
3. washThe combined organic layer is washed with brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo