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HRID458333

反应详情

EQUATION

反应方程式

HRID 458333 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CO
HCID887

Methanol

CH4O

2 次

结构：O=C(O)[C@@H]1C[C@@H](O)CN1S(=O)(=O)c1ccc2ccccc2c1
HCID6363699

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@H](O)CN1S(=O)(=O)c1ccc2ccccc2c1
HCID7987003

未命名化合物

PROCEDURE

实验过程

38.97 g (121.4 mmol) (2S,4R)-4-hydroxy-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid were dissolved in 97 ml MeOH and 64.5 ml 1.75 M (112.8 mmol) HCl in MeOH were added and the solution heated to reflux for 3 h and concentrated. Trituration with hexane yielded 41.4 g (quant.) (2S,4R)-4-hydroxy-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester as brown solid, MS: 335 (MH+).

WORKUP

后处理

  1. temperaturethe solution heated
  2. temperatureto reflux for 3 h
  3. concentrationconcentrated